Entrez 7203 | Ensembl ENSG00000163468 | |
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Aliases CCT3, CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5, chaperonin containing TCP1 subunit 3 External IDs MGI: 104708 HomoloGene: 4373 GeneCards: CCT3 | ||
Function
This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
CCT3 has been shown to interact with PPP4C.
References
CCT3 Wikipedia(Text) CC BY-SA