Species Human Entrez 1232 | Human Mouse Ensembl ENSG00000183625 | |
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Aliases CCR3, CC-CKR-3, CD193, CKR3, CMKBR3, C-C motif chemokine receptor 3 External IDs MGI: 104616 HomoloGene: 20436 GeneCards: CCR3 | ||
C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.
Contents
CCR3 has also recently been designated CD193 (cluster of differentiation 193).
Function
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.
Interactions
CCR3 (gene) has been shown to interact with CCL5.