Species Human Entrez 863 | Human Mouse Ensembl ENSG00000129993 | |
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Aliases CBFA2T3, ETO2, MTG16, MTGR2, ZMYND4, RUNX1T3, CBFA2/RUNX1 translocation partner 3 External IDs MGI: 1338013 HomoloGene: 74543 GeneCards: CBFA2T3 | ||
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.
Contents
Function
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.
Interactions
CBFA2T3 has been shown to interact with:
References
CBFA2T3 Wikipedia(Text) CC BY-SA