Species Human Entrez 9994 | Human Mouse Ensembl ENSG00000118412 | |
Aliases CASP8AP2, CED-4, FLASH, RIP25, caspase 8 associated protein 2 External IDs MGI: 1349399 HomoloGene: 8066 GeneCards: CASP8AP2 | ||
CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.
Contents
Function
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
Interactions
CASP8AP2 has been shown to interact with TRAF2.
References
CASP8AP2 Wikipedia(Text) CC BY-SA