Species Human Entrez 826 | Human Mouse Ensembl ENSG00000126247 | |
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Aliases CAPNS1, 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, calpain small subunit 1 External IDs MGI: 88266 HomoloGene: 1327 GeneCards: CAPNS1 | ||
Calpain small subunit 1, also known as CAPN4, is a protein that in humans is encoded by the CAPNS1 gene.
Contents
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Two transcript variants encoding the same protein have been identified for this gene.
Myotonic dystrophy
This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.
Biomarker
Elevated expression of Capn4 has been found to be associated with progression of various cancers such as hepatocellular and renal carcinoma.