Species Human Entrez 824 | Human Mouse Ensembl ENSG00000162909 | |
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Aliases CAPN2, CANP2, CANPL2, CANPml, mCANP, calpain 2 External IDs MGI: 88264 HomoloGene: 1326 GeneCards: CAPN2 | ||
Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.
Contents
Function
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.
Interactions
CAPN2 has been shown to interact with Bcl-2.
References
CAPN2 Wikipedia(Text) CC BY-SA