Species Human Entrez 823 | Human Mouse Ensembl ENSG00000014216 | |
 | ||
Aliases CAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1 External IDs MGI: 88263 HomoloGene: 3800 GeneCards: CAPN1 | ||
Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene.
Contents
Function
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.
Interactions
CAPN1 has been shown to interact with PSEN2.
References
CAPN1 Wikipedia(Text) CC BY-SA