Entrez 816 | Ensembl ENSG00000058404 | |
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Aliases CAMK2B, CAM2, CAMK2, CAMKB, calcium/calmodulin dependent protein kinase II beta External IDs MGI: 88257 HomoloGene: 111050 GeneCards: CAMK2B | ||
Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.
Contents
Function
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.
Interactions
CAMK2B has been shown to interact with Actinin alpha 4.