Species Human Entrez 815 | Human Mouse Ensembl ENSG00000070808 | |
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Aliases CAMK2A, CAMKA, calcium/calmodulin dependent protein kinase II alpha External IDs MGI: 88256 HomoloGene: 56577 GeneCards: CAMK2A | ||
Calcium/calmodulin-dependent protein kinase type II alpha chain (CAMKIIα) is an enzyme that in humans is encoded by the CAMK2A gene.
Contents
Function
The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning(needs citation, perhaps Harvward et al 2016). In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
Interactions
CAMK2A has been shown to interact with: