Species Human Entrez 770 | Human Mouse Ensembl ENSG00000063180 | |
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Aliases CA11, CARPX1, carbonic anhydrase 11 External IDs MGI: 1336193 HomoloGene: 36061 GeneCards: CA11 | ||
Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.
Contents
Function
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.
Interactions
CA11 has been shown to interact with RIPK1.