Trade names Gynazole-1, Mycelex-3 MedlinePlus a682012 ATC code G01AF15 (WHO) | AHFS/Drugs.com Monograph Routes ofadministration Vaginal cream | |
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Pregnancycategory US: C (Risk not ruled out) | ||
Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.
Synthesis
Reaction of epichlorohydrin with 4-chlorophenylbenzylmganeium chloride leads to 1-chloro-4-(4-chlorophenyl)butan-2-ol (3). Displacement with sodium imidazole, conversion of the secondary alcohol to the chloride (SOCl2), and displacement with 2,6-dichlorobenzenethiol concludes the synthesis of the antifungal butoconazole.
References
Butoconazole Wikipedia(Text) CC BY-SA