Bustamante is a surname originating in the town Bustamante which is part of the Cantabria region in northern Spain. Notable people with the surname include:
Alexander Bustamante (William Alexander Clarke Bustamante) (1884–1977), Jamaican politician and labor leaderAnastasio Bustamante (1780–1853), President of Mexico 1830–1832 and 1837–1841Antonio Sánchez de Bustamante y Sirven (1865–1951), Cuban juristCarlos Bustamante (1951—), American scientist, professor of biology, physics, and chemistryCarlos María Bustamante, Mexican statesman and historian (1774- 1848)Cruz Bustamante (1953—), American politician, Lieutenant Governor of California (1999—2007)David Bustamante (1982—), Spanish singerErnesto Bustamante (1950—), Peruvian scientist, professor, and entrepreneurFrancisco “Django” Bustamante (1963—), Filipino pocket billiards playerFrancisco Bustamante (painter) (died 1737), Spanish painterGladys Bustamante (1912-2009), Jamaican activistHector Luis Bustamante (1972—), Colombian actorJean-Marc Bustamante (1952—), French artist, sculptor, and photographerJosé Bustamante y Rivero (1894–1989), President of Peru 1945–1948José de Bustamante y Guerra (1759–1825), Spanish naval officer, explorer, and politicianJosé María Bustamante (1777–1861), Mexican composerManela Bustamante (1924–2005), Cuban-Puerto Rican actressMariano Bustamante (1831–1879), Peruvian war heroMonika Bustamante (contemporary), Anime performerMurilo Bustamante (contemporary), Brazilian martial arts championRic Bustamante (1923—), Filipino actorTeodoro Sánchez de Bustamante (1778–1851), Argentine statesman, lawyer and soldier.