Aniston was born in Huntington Beach and raised in Riverside County, California. She is of Armenian and Thai descent. She is a trained actress, model, singer, and dancer.
Aniston was stripping at the Spearmint Rhino in Industry, California when she was approached by several pornographic actresses who were feature dancing at the club and they encouraged her to enter the adult film industry. Pornographic actress Shy Love, who was once Aniston's agent, came up with her stage name.
Aniston portrayed the Wicked Witch in the 2013 adult film parody Not the Wizard of Oz XXX. She won the 2014 AVN Award for Best Supporting Actress for her role in the film.
Aniston was among the fifteen pornographic actresses to appear in the music video for the song "YouPorn.com" by Brian McKnight.
In October 2013, Aniston was interviewed alongside several mainstream celebrities, such as Kanye West, Selena Gomez, James Franco, Juliette Lewis, and Shaun White, for a short documentary preceding the music video for the song "City of Angels" by Thirty Seconds to Mars.
Aniston hosts a show titled In With Aniston on Vivid Radio, Sirius XM 102.
In 2014, Aniston made her directorial debut with a BDSM pornographic film titled Brandy Aniston Is Fucked for Deviant Entertainment. The film won Best BDSM Release in 2015 at the 32nd AVN Awards.
In June 2014, Aniston launched her own clothing line, BfknAniston, with Sex Addict Clothing after becoming a model for them a month earlier. On September 18, 2014, she launched another clothing line with Sex Addict Clothing titled Queen B.
In a 2011 interview, Aniston stated that she was enrolled in school and majoring in finance. As of 2014, she is taking a hiatus from school to focus on her adult entertainment career.
Aniston is married to pornographic actor Barry Scott. She has a son.