Species Human Entrez 577 | Human Mouse Ensembl ENSG00000135298 | |
Aliases ADGRB3, BAI3, adhesion G protein-coupled receptor B3 External IDs MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3 | ||
Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.
The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain. BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.