Brain is a surname.
Those bearing it include:
Aubrey Brain (1893–1955), British French hornist
Benjamin Brain (1753-1794), British boxer
Brian Brain (born 1940), British cricketer
Charles Kimberlin Brain (born 1931), South African paleontologist
Dave Brain (1879-1959), American baseball player
David Brain (born 1964), Zimbabwean cricketer
Dennis Brain (1921-1957), British French hornist
Errol Brain, New Zealand rugby player
George Brain (1893-1969), Australian politician
Jimmy Brain (1900-1971), British football player
Jonny Brain (born 1983), British football goalkeeper
Lester Brain (1903–1980), Australian air force office and airline executive
Louis Brain (born 1982), English-Australian football player
Marshall Brain (born 1961), American computer scientist and entrepreneur
Matias Brain (born 1974), Chilean triathlete
Peter Brain (born 1947), Australian bishop
Russell Brain (1895–1966), British neurologist
Terence Brain (born 1938), British bishop
Terry Brain (born 1907), Australian rules football player
Terry Brain, Jr. (born 1938), Australian rules football player
Terry Brain (animator) (born 1956), animator
Tim Brain (born 1954), British police chief