Species Human Entrez 624 | Human Mouse Ensembl ENSG00000168398 | |
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Aliases BDKRB2, B2R, BK-2, BK2, BKR2, BRB2, bradykinin receptor B2 External IDs MGI: 102845 HomoloGene: 519 GeneCards: BDKRB2 | ||
Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.
Contents
Mechanism
The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.
Kallidin also signals through the B2 receptor. An antagonist for the receptor is Hoe 140 (icatibant).
Function
The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.
Gene
Alternate start codons result in two isoforms of the protein.