Entrez 9210 | Ensembl ENSG00000130385 | |
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External IDs OMIM: 300247 MGI: 1316745 HomoloGene: 3977 GeneCards: BMP15 |
Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene. It's mainly involved in folliculogenesis.
Contents
Structure and expression
The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.
Functions
The functions of BMP15 include:
Defects in BMP15 are associated with primary ovarian insufficiency. BMP15may represent a biomarker of ovarian response to ovarian stimulation or oocyte quality.
References
Bone morphogenetic protein 15 Wikipedia(Text) CC BY-SA