Species Human Entrez 680 | Human Mouse Ensembl ENSG00000102239 | |
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Aliases BRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3 External IDs OMIM: 300107 MGI: 1100501 HomoloGene: 1307 GeneCards: BRS3 | ||
The bombesin receptor subtype 3 also known as BRS-3 or BB3 is a protein which in humans is encoded by the BRS3 gene.
Function
Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).
BB3 is a G protein-coupled receptor. BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.