Bledsoe is a surname. Notable people with the surname include:
Albert Taylor Bledsoe (1809 – 1877), American educator, attorney, author, and clergyman
Ben Bledsoe (born 1982), American pop singer
Benjamin Franklin Bledsoe (1874 - 1938), American federal judge
Curtis Bledsoe (born 1957), former American football player
Drew Bledsoe (born 1972), former American football quarterback
Eric Bledsoe (born 1989), American basketball player
Fred Bledsoe (born 1986), American football defensive tackle
Jerry Bledsoe (born 1941), American author and journalist
Jesse Bledsoe (1776 - 1836), Senator from Kentucky
John Bledsoe (born 1968), American software executive
Jules Bledsoe (1898 - 1943), African American singer
Lucy Jane Bledsoe (born 1957), American novelist and science writer
Neal Bledsoe (born 1981), Canadian actor
Samuel T. Bledsoe (1868 - 1939), American railroad executive
Tempestt Bledsoe (born 1973), American actress
Tim Bledsoe (born 1953), American politician and college professor
William H. Bledsoe (1869-1936), American politician
Woody Bledsoe (1921 - 1995), American mathematician and computer scientist