Blackwell is a surname of British origin. Notable people with the surname include:
A. J. Blackwell (Andrew Jackson Blackwell, 1842–1903), American founder of and namegiver to Blackwell, Kay County, Oklahoma
Adam Blackwell (active from 2002–after 2005), Canadian diplomat
Alan F. Blackwell (born 1962), New Zealand-British cognition scientist
Alex Blackwell (basketball) (Robert Alexander "Alex" Blackwell, born 1970), American basketball player
Alex Blackwell (cricketer) (born 1983), female cricketer for New South Wales and Australia, identical twin sister of Kate
Alexander Blackwell (c.1700–1747), Scottish adventurer, husband of Elizabeth Blackwell
Alfonzo Blackwell (born 1971), American jazz musician, composer and producer
Alice Stone Blackwell (1857–1950), American feminist, suffragist, journalist and human rights advocate
Angela Glover Blackwell (active from 1977), American founder and president of PolicyLink
Antoinette Brown Blackwell (born Antoinette Louisa Brown, 1825–1921), American preacher and activist, first woman ordained as minister in the USA, wife of Samuel C. Blackwell
Sir Basil Blackwell (1889–1984), English publisher, son of Benjamin Henry Blackwell
Ben Blackwell (born 1982), American musician, writer and archivist, founder of Cass Records
Benjamin Henry Blackwell (1849–1924), English bookseller and politician, founder of Blackwell's chain of bookshops
Betsy Blackwell (1905–85), American editor of women's magazines
Brian Blackwell (born 1986), English schoolboy convicted of the manslaughter of his parents
Bubba Blackwell (born 1966), American stunt performer and motorcycle jumping world record holder
"Bumps" Blackwell (Robert Blackwell, 1918–85), American bandleader, songwriter, arranger and record producer
Caesar Blackwell (1769–1845), enslaved African-American preacher
Carlyle Blackwell (1884–1955), American silent film actor, director and producer
Charles Blackwell (disambiguation), multiple people
Charlie Blackwell (Charles H. "Rucker" Blackwell, 1894–1935), American Negro League baseball player
Chris Blackwell (born 1937), English founder of Island Records
Cory Blackwell (born 1963), American basketball player
"Crusher" Blackwell (Jerry Blackwell, (1949–95), American professional wrestler
David Blackwell (1919–2010), American mathematician
Dean Blackwell (born 1969), English footballer
Deborah Blackwell (1950–2014), American television executive
Dewayne Blackwell (born 1939), American songwriter
Donald Blackwell (1921–2010), British astronomer
Douglas Blackwell (1924–2009), British actor
Ed Blackwell (1929–92), American jazz drummer
Edith Winstone Blackwell (1877–1956), New Zealand philanthropist
Edward Blackwell (official), 17th century English merchant and public official
Elise Blackwell (born 1964), American novelist
Elizabeth Blackwell (illustrator) (1707–1758), Scottish botanical illustrator and author, wife of Alexander Blackwell
Elizabeth Blackwell (doctor) (1821–1910), British-American physician, first woman to receive a medical degree in the US, first woman on the UK Medical Register, sister of Emily and Sarah
Ellen Wright Blackwell (1864–1952), writer and botanist influential in New Zealand
Emily Blackwell (1826–1910), British-American physician, one of the first American women physicians, sister of Elizabeth (physician) and Sarah
Ernest Blackwell (1894–1964), English footballer
Sir Ernley Blackwell (1868–1941), British lawyer and civil servant
Ewell Blackwell (1922–96), American baseball pitcher
Fred Blackwell (1891–1975), American baseball player
Garie Blackwell (active from 1968–after 1971), American painter and illustrator
Genieve Blackwell (active from 1989), Australian female Anglican bishop
George Blackwell (c.1545–1613), English Roman Catholic Archpriest
George Lincoln Blackwell (1861–1926), African-American author and bishop
Gloria Blackwell (1927–2010), African-American civil rights activist and educator
Grey Blackwell (born 1969), American illustrator and animator
Hal Blackwell (active 2010), American financial analyst and author
Harolyn Blackwell (born 1955), American theatrical and classical soprano
Harry Blackwell (1900–56), English footballer
Henry Blackwell (disambiguation), multiple people
Hugh Blackwell (born 1944), American politician (North Carolina)
Ian Blackwell (born 1978), English cricketer
Isaac Blackwell (before 1664–99), English organist and composer
Jack Blackwell (1909–2001), English footballer
James Blackwell (born 1968), American basketball player
James Bartholomew Blackwell (1763–after 1819), Irish-born mercenary and French Army officer
James DeRuyter Blackwell (1828–1901), American author and poet
Jannie L. Blackwell (active from 1992), American politician (Philadelphia), widow of Lucien E. Blackwell
Jerry Blackwell ("Crusher" Blackwell, 1949–95), American professional wrestler
John Blackwell (disambiguation), multiple people
Julius W. Blackwell (1797–after 1845), US Congressman from Tennessee
Kate Blackwell (born 1983), Australian female cricketer for New South Wales and Australia, identical twin sister of Alex
Keith R. Blackwell (active after 2012), American judge (Georgia)
Kelly Blackwell (born 1969), American football player
Ken Blackwell (born 1948), American politician and activist in Ohio
Kevin Blackwell (born 1948), English football goalkeeper and manager
Kory Blackwell (born 1972), American football player
Leslie Blackwell (1897–1959), Canadian politician, soldier, lawyer and land developer
Lucien E. Blackwell (1931–2003), U.S. Congressman from Pennsylvania, husband of Jannie L. Blackwell
Luke Blackwell (born 1986), Australian Rules footballer
Marlon Blackwell (active from 1996–at least 2014), American architect and academic
Marquel Blackwell (born 1979), American football player
Morton Blackwell (born 1939), American conservative political activist
Nate Blackwell (born 1965), American basketball player
Nick Blackwell (born 1990), British professional boxer
Nigel Blackwell (born 1963), British frontman and songwriter of the band Half Man Half Biscuit
Norman Blackwell, Baron Blackwell (born 1952) British businessman, public servant, politician, campaigner and policy advisor
Olin G. Blackwell (1915–86) American prison official, fourth and final warden of Alcatraz Federal Penitentiary
Otis Blackwell (1931–2002), American songwriter, singer, and pianist
Otto B. Blackwell (1884–1970), American electrical engineer
Pam Blackwell (born 1942), American Jungian educator and theorist, playwright and novelist
Paul Blackwell (born 1954), Australian actor
Paul Blackwell (footballer) (born 1963), Welsh footballer
Pip Blackwell (Phil "Pip" Blackwell, born 1974), English darts player
Randolph Blackwell (1927–81), American civil rights activist
Richard Blackwell (MP) (by 1517–1568), English Member of Parliament
Richard Blackwell ("Mr. Blackwell", 1922–2008), American fashion critic best known for his annual "worst dressed" lists
Robby Blackwell (born 1986), American singer-songwriter, producer, and instrumentalist
Robert Blackwell ("Bumps" Blackwell, 1918–85), American bandleader, songwriter, arranger, and record producer
Robert J. Blackwell (born 1925), American maritime administrator
Robert L. Blackwell (1895–1918), American Medal of Honor recipient
Roger Blackwell (active from 1999), American marketing expert and public speaker
Rory Blackwell (born 1933), British rock and roll musician
"Rucker" Blackwell, (Charlie Blackwell, 1894–1935), American Negro League baseball player
S. L. Blackwell (c. 1833–after 1878), American miner and politician (California)
Samuel Charles Blackwell (1823–1901), Anglo-American abolitionist, husband of Antoinette Brown Blackwell
Sarah Ellen Blackwell (1828–1901), American biographer and artist; sister of Elizabeth (physician) and Emily
Scott Blackwell (active from 1992–after 2011), American disk jockey and Christian dance music artist
Scrapper Blackwell (Francis Hillman "Scrapper" Blackwell, 1903–62), American blues musician
Simon Blackwell (born 1966), British comedy writer and producer
Slade Blackwell (born 1968), American politician (Alabama)
Susan Blackwell (active from 1995–after 2008), American actress
Thomas Blackwell (disambiguation), multiple people
Tim Blackwell (born 1952), American baseball player
Tom Blackwell (born 1938), American photorealist painter
Trevor Blackwell (born 1969), Canadian computer programmer, engineer and entrepreneur
Unita Blackwell (born 1933), American civil rights activist, the first African-American woman to be elected mayor in the state of Mississippi
Victor Blackwell (born 1981), American journalist and television news anchor
W. Blackwell (fl.1835), English cricketer
Wayne Blackwell (born 1960), Australian Rules footballer
Will Blackwell (born 1975), American football player
William Blackwell (disambiguation), multiple people