EC number 3.6.1.29 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 63951-94-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) is an enzyme that catalyzes the chemical reaction
P1,P3-bis(5'-adenosyl) triphosphate + H2OThus, the two substrates of this enzyme are P1,P3-bis(5'-adenosyl) triphosphate and H2O, whereas its two products are ADP and AMP.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in common use include dinucleosidetriphosphatase, diadenosine 5,5-P1,P3-triphosphatase, and 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase. This enzyme participates metabolic pathways involved in purine metabolism, and may have a role in the development of small cell lung cancer, and non-small cell lung cancer.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1FHI, 2FHI, 4FIT, 5FIT, and 6FIT.