Birrell is a surname. Notable people with the surname include:
Adrian Birrell (born 1960), former South African first class cricketer and Irish cricket coach
Alec Birrell (born 1885), Australian rules footballer
Augustine Birrell (1850–1933), English politician, barrister, academic and author
Billy Birrell (1897–1968), Scottish football player and manager
Fred Birrell (1913–1985), Australian politician
Gerry Birrell (1944–1973), Scottish racing driver
Harry Birrell (cricketer) (1927–2003), South African cricketer and schoolmaster
James Birrell (born 1928), retired architect who worked in Queensland, Australia
John Birrell (1815–1875), railway entrepreneur
Mark Birrell (born 1958), solicitor, director and a former Cabinet Minister in Victoria, Australia
Niki Birrell (born 1986), British Paralympic sailor
Peter Birrell (born 1941), British musician in the band, Freddie and the Dreamers