ATC code none IUPHAR/BPS 3954 ChEMBL CHEMBL593013 Molar mass 454.556 g/mol | PubChem CID 9868580 ChemSpider 8044271 Formula C30H30O4 | |
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Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.
In animal studies it showed anxiolytic and antipsychotic effects, and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.
BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR2/3 agonist LY-379,268
References
Biphenylindanone A Wikipedia(Text) CC BY-SA