CAS Number 191471-52-0 ChemSpider 8373484 3D model (Jmol) Interactive image | PubChem CID 10197984 Formula C7H9NO5 Molar mass 187.15 g/mol | |
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LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).
It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia in animals.
There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.
References
LY-379,268 Wikipedia(Text) CC BY-SA