Biotin—(acetyl CoA carboxylase) ligase

Updated on Dec 09, 2024

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EC number 6.3.4.15 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 37340-95-7 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15) is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ⇌ AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.

This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.

Nomenclature

The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include:

biotin-[acetyl-CoA carboxylase] synthetase,

biotin-[acetyl coenzyme A carboxylase] synthetase,

acetyl coenzyme A holocarboxylase synthetase,

acetyl CoA holocarboxylase synthetase,

biotin:apocarboxylase ligase,

biotin holoenzyme synthetase,

and HCS.

References

Biotin—(acetyl-CoA-carboxylase) ligase Wikipedia

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