William Cole may refer to:
Politics and government
William Colle, MP for Leominster first elected in 1397William Cole, 1st Earl of Enniskillen (1736–1803), Irish peer and politicianWilliam Cole, 3rd Earl of Enniskillen (1807–1886), known as Viscount ColeWilliam Hinson Cole (1837–1886), U.S. Congressman from MarylandWilliam Purington Cole, Jr. (1889–1957), U.S. Congressman from MarylandWilliam Clay Cole (1897–1965), U.S. Congressman from MissouriW. Sterling Cole (1904–1987), U.S. Congressman from New York and first Director General of the International Atomic Energy AgencySir William Cole (public servant) (born 1926), Australian senior public servantWilliam H. Cole IV (born 1972), City Councilman from Baltimore, Maryland (2007–present); former Delegate in Maryland General Assembly (1999–2002)Bill Cole (politician), West Virginia politicianScholarship and science
William Cole (botanist) (1626–1662), English herbalist known for the doctrine of signaturesWilliam Cole (antiquary) (1714–1782), clergyman and antiquaryWilliam Cole (scholar) (1753–1806), English classical scholar, writer and churchmanArts and entertainment
William Washington Cole (1847–1915), part owner of the Barnum & Bailey CircusWilliam Cole (musician) (1909–1997), conductor, composer and organistWilliam Rossa Cole (1919–2000), American writer and poetBill Cole (musician) (born 1937), American jazz musician and professorMilitary and police
William Carey Cole (1868–1935), U.S. Navy admiralWilliam E. Cole (1874–1953), U.S. Army generalWilliam Cole (police officer) (died 1900), British policeman, who was awarded the Albert Medal for braveryWilliam C. "King" Cole (1881–1968), American college football player and coachBilly Cole (born 1965), English shot putterWilliam Cole (Dean of Lincoln) (c. 1530–1600), Anglican priest and President of Corpus Christi College, OxfordWilliam Cole (Dean of Waterford) (died 1804), Dean of WaterfordWilliam Horace de Vere Cole (1881–1936), prankster and perpetrator of the Dreadnaught HoaxWilliam Cole, a fictional character from the 2005 film Man with the Screaming Brain