William Cole may refer to:
Politics and government
William Colle, MP for Leominster first elected in 1397
William Cole, 1st Earl of Enniskillen (1736–1803), Irish peer and politician
William Cole, 3rd Earl of Enniskillen (1807–1886), known as Viscount Cole
William Hinson Cole (1837–1886), U.S. Congressman from Maryland
William Purington Cole, Jr. (1889–1957), U.S. Congressman from Maryland
William Clay Cole (1897–1965), U.S. Congressman from Missouri
W. Sterling Cole (1904–1987), U.S. Congressman from New York and first Director General of the International Atomic Energy Agency
Sir William Cole (public servant) (born 1926), Australian senior public servant
William H. Cole IV (born 1972), City Councilman from Baltimore, Maryland (2007–present); former Delegate in Maryland General Assembly (1999–2002)
Bill Cole (politician), West Virginia politician
Scholarship and science
William Cole (botanist) (1626–1662), English herbalist known for the doctrine of signatures
William Cole (antiquary) (1714–1782), clergyman and antiquary
William Cole (scholar) (1753–1806), English classical scholar, writer and churchman
Arts and entertainment
William Washington Cole (1847–1915), part owner of the Barnum & Bailey Circus
William Cole (musician) (1909–1997), conductor, composer and organist
William Rossa Cole (1919–2000), American writer and poet
Bill Cole (musician) (born 1937), American jazz musician and professor
Military and police
William Carey Cole (1868–1935), U.S. Navy admiral
William E. Cole (1874–1953), U.S. Army general
William Cole (police officer) (died 1900), British policeman, who was awarded the Albert Medal for bravery
William C. "King" Cole (1881–1968), American college football player and coach
Billy Cole (born 1965), English shot putter
William Cole (Dean of Lincoln) (c. 1530–1600), Anglican priest and President of Corpus Christi College, Oxford
William Cole (Dean of Waterford) (died 1804), Dean of Waterford
William Horace de Vere Cole (1881–1936), prankster and perpetrator of the Dreadnaught Hoax
William Cole, a fictional character from the 2005 film Man with the Screaming Brain
