In number theory, a bi-twin chain of length k + 1 is a sequence of natural numbers
                    n        −        1        ,        n        +        1        ,        2        n        −        1        ,        2        n        +        1        ,        …        ,                  2                      k                          n        −        1        ,                  2                      k                          n        +        1                        in which every number is prime.
The numbers                     n        −        1        ,        2        n        −        1        ,        …        ,                  2                      k                          n        −        1                 form a Cunningham chain of the first kind of length                     k        +        1                , while                     n        +        1        ,        2        n        +        1        ,        …        ,                  2                      k                          n        +        1                 forms a Cunningham chain of the second kind. Each of the pairs                               2                      i                          n        −        1        ,                  2                      i                          n        +        1                 is a pair of twin primes. Each of the primes                               2                      i                          n        −        1                 for                     0        ≤        i        ≤        k        −        1                 is a Sophie Germain prime and each of the primes                               2                      i                          n        −        1                 for                     1        ≤        i        ≤        k                 is a safe prime.
q# denotes the primorial 2×3×5×7×...×q.
As of 2014, the longest known bi-twin chain is of length 8.
Cunningham chainTwin primesSophie Germain prime is a prime                     p                 such that                     2        p        +        1                 is also prime.Safe prime is a prime                     p                 such that                     (        p        −        1        )                  /                2                 is also prime.