Name Bharat Aggarwal | ||
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Institutions MD Anderson Cancer CenterGenentech Books Healing Spices: How to Use 50 Everyday and Exotic Spices to Boost Health and Beat Disease Institution | ||
Curry to prevent cancer an interview with dr bharat aggarwal
Bharat B. Aggarwal is an Indian-American biochemist. His research has been in the areas of cytokines, the role of inflammation in cancer, and the anti-cancer effects of spices and herbs, particularly those of curcumin (a chemical constituent of the spice turmeric). He was a professor in the Department of Clinical Immunology, Bioimmunotherapy, and Experimental Therapeutics at University of Texas MD Anderson Cancer Center in Houston, Texas, a position from which he retired in 2015 following allegations of fraud in his research.
Contents
- Curry to prevent cancer an interview with dr bharat aggarwal
- Dr Bharat Aggarwal Explaining About Curcumin C3 Complex
- Career
- Scientific misconduct
- Retracted Articles
- Books
- References
In 2012, MD Anderson launched a review of Aggarwal’s research after the federal government notified them of allegations of fraud by academic whistleblowers in as many as 65 of Aggarwal's published papers, one of which had been retracted by the journal that published it. Several more of Aggarwal's publications were subsequently retracted after they were found to contain data images that had been reused and manipulated to represent different results. Aggarwal resigned from his position at MD Anderson at the end of 2015. By August 2016, eighteen research articles published by Aggarwal (in seven scientific journals) had been retracted.
Dr. Bharat Aggarwal Explaining About Curcumin C3 Complex
Career
Aggarwal holds a Bachelor of Science degree from the University of Delhi (1970), a Master of Science degree from Banares Hindu University (1972) and a Doctor of Philosophy degree from the University of California, Berkeley (1977), all in Biochemistry. He completed a postdoctoral fellowship at the University of California, San Francisco and was employed as a scientist at Genentech from 1980 to 1989, where his team characterized the cytokines TNF-alpha and TNF-beta. Aggarwal then served as Chief of the Cytokine Research Section, Department of Clinical Immunology, Bioimmunotherapy, Experimental Therapeutics at MD Anderson Cancer Center of the University of Texas in Houston from 1989 to 2015. He has published over 500 articles and is an ISI Highly Cited Researcher. As of 2016, he had an h-index of 160 and 94,234 citations to 433 articles.
Aggarwal's research has focused on potential anti-cancer properties of herbs and spices, particularly curcumin, found in the spice turmeric. In 1996, Aggarwal patented curcumin as an inhibitor of NF-κB activation, and he co-founded a company in 2004 called Curry Pharmaceuticals, based in Research Triangle Park, N.C., which was seeking to develop drugs based on synthetic analogs of curcumin.
Scientific misconduct
In 2012, MD Anderson initiated a review of Aggarwal's research after the U.S. Department of Health and Human Services' Office of Research Integrity notified the institution that academic whistleblowers had found evidence of image manipulation in 65 published papers by Aggarwal.
Aggarwal's lawyer proposed legal action against the blog Retraction Watch in 2013 after they wrote about several of his article corrections and retractions. In February 2016, the journal Biochemical Pharmacology retracted seven research articles with Aggarwal as a co-author, him being senior or first author on six of these. The retraction notices stated this was "because the data integrity has become questionable". In 2016, following an investigation by MD Anderson Cancer Center, the journal Molecular Pharmacology retracted two papers coauthored by Aggarwal, citing “inappropriate” or “unacceptable” image manipulation. All told, 19 of Aggarwal's articles, published in 7 research journals, were ultimately retracted by the publishers.
MD Anderson Cancer Center confirmed to Retraction Watch that Aggarwal retired from the institute on December 31, 2015. In January 2016, an article in The Times of India listed Aggarwal as the founder director of the Anti-inflammation Research Institute in San Diego, California. Retraction Watch noted that the institute does not have a functioning website.
Retracted Articles
- Biochem Pharmacol. 2007 Apr 1;73(7):1024-32. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:147.
- Biochem Pharmacol. 2010 Jan 15; 79(2): 218–228. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 145.
- Biochem Pharmacol. 2010 Feb 1; 79(3): 330–338. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 143.
- Biochem Pharmacol. 2010 Jun 1; 79(11): 1640–1647. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 146.
- Biochem Pharmacol. 2010 Oct 1; 80(7): 1021–1032. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 142.
- Biochem Pharmacol. 2011 Nov 1; 82(9): 1134–1144. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 141.
- Biochem Pharmacol. 2011 Dec 15; 82(12): 1901–1909. Retraction in: Biochem Pharmacol. 2016 Feb 15; 102: 144.
- Biochim Biophys Acta. 2012 Jan 10. (Epub ahead of print). Withdrawn.
- Cancer Lett. 2011 Dec 17. (Epub ahead of print). Withdrawn.
- J Biol Chem. 2010 Apr 9; 285(15): 11498–11507. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16920.
- J Biol Chem. 2010 Aug 27; 285(35): 26987–26997. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16921.
- J Biol Chem. 2010 Nov 12; 285(46): 35418–35427. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16923.
- J Biol Chem. 2010 Oct 22; 285(43): 33520–33528. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16922.
- J Biol Chem. 2011 Jan 14; 286(2): 1134–1146. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16925.
- J Biol Chem. 2011 Feb 18; 286(7): 5546–5557. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16924.
- J Biol Chem. 2012 Jan 2; 287(1): 245–256. Retraction in: J Biol Chem. 2016 Aug 5; 291(32): 16926.
- Mol Pharmacol. 2008 May; 73(5): 1549–1557. Retraction in: Mol Pharmacol. 2016 Jul; 90(1): 63.
- Mol Pharmacol. 2011 Feb; 79(2): 279–289. Retraction in: Mol Pharmacol. 2016 Jul; 90(1): 64.