Betty Lou is a feminine double name. Notable people with the name include:
Betty Lou Bailey (1929–2007), American mechanical engineerBetty Lou Beets (1937–2000), murderer executed in TexasBetty Lou Bredemus (1934–2015), American actress and acting coachBettyLou DeCroce (born 1952), American politician from New JerseyBetty Lou Gerson (1914–1999), American actressBetty Lou Holland (born 1926), American actressBetty Lou Keim (1938–2010), American actressBetty Lou Mitchell (born 1937), American politician from MaineBetty Lou Varnum (born 1931), American television personalityBetty Lou Young (1919–2010), American writer and conservationist