Neha Patil (Editor)

Beta 1 adrenergic receptor

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Species
  
Human

Entrez
  
153

Human
  
Mouse

Ensembl
  
ENSG00000043591

Beta-1 adrenergic receptor

Aliases
  
ADRB1, ADRB1R, B1AR, BETA1AR, RHR, adrenoceptor beta 1

External IDs
  
OMIM: 109630 MGI: 87937 HomoloGene: 20171 GeneCards: ADRB1

The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.

Contents

Actions

Actions of the β1 receptor include:

  • stimulate viscous, amylase-filled secretions from salivary glands
  • Increase cardiac output
  • Increase heart rate in sinoatrial node (SA node) (chronotropic effect)
  • Increase atrial cardiac muscle contractility. (inotropic effect)
  • Increases contractility and automaticity of ventricular cardiac muscle.
  • Increases conduction and automaticity of atrioventricular node (AV node)
  • Renin release from juxtaglomerular cells.
  • Lipolysis in adipose tissue.
  • Relaxation of the urinary bladder wall
  • Receptor also present in cerebral cortex.

    • Agonists

    Isoprenaline has higher affinity for β1 than adrenaline, which, in turn, binds with higher affinity than noradrenaline at physiologic concentrations. Selective agonists to the beta-1 receptor are:

  • Denopamine
  • Dobutamine (in cardiogenic shock)
  • Xamoterol (cardiac stimulant)

    • Antagonists

    (Beta blockers) β1-selective ones are:

  • Acebutolol (in hypertension, angina pectoris and arrhythmias)
  • Atenolol (in hypertension, coronary heart disease, arrhythmias and myocardial infarction)
  • Betaxolol (in hypertension and glaucoma)
  • Bisoprolol (in hypertension, coronary heart disease, arrhythmias, myocardial infarction and ischemic heart diseases)
  • Esmolol (in arrhythmias)
  • Metoprolol (in hypertension, coronary heart disease, myocardial infarction and heart failure)
  • Nebivolol (in hypertension)
  • Vortioxetine (antidepressant)

    • Mechanism

    Gs renders adenylate cyclase activated, resulting in increase of cAMP.

    Gene

    Specific polymorphisms in the ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.

    Interactions

    Beta-1 adrenergic receptor has been shown to interact with DLG4 and GIPC1. Interaction between testosterone and β-1 ARs have been shown in anxiolytic behaviors in the basolateral amygdala.

    References

    Beta-1 adrenergic receptor Wikipedia
    (Text) CC BY-SA


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