EC number 4.1.1.7 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9025-00-7 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, a benzoylformate decarboxylase (EC 4.1.1.7) is an enzyme that catalyzes the following chemical reaction:
benzoylformate + H+Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1BFD, 1MCZ, 1PI3, 1PO7, 1Q6Z, 1YNO, 2FN3, and 2FWN.