Supriya Ghosh (Editor)

Benzhydryl compounds

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Benzhydryl compounds

Benzhydryl compounds are compounds that are "diphenylmethane"-containing, i.e. two benzene rings adjoining a single carbon. This simple definition does not include heteroaromatic ring moieties, which would complicate the situation even further. Although it may still be desired to include these for the purposes of 'completeness' they ought to be kept separate to avoid confusion. Benzhydryl can be abbreviated to CHPh2 or Bzh.

Contents

Alcohols

  • Acyclic: pridinol
  • Pyrolidino: diphenylprolinol
  • 2-Piperidine: pipradrol
  • 4-Piperidine: terfenadine, fexofenadine
  • Benzilic ester: QNB, JB-336, JB-318, benactyzine

    • Alkenes

  • Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol chlorprothixene flupentixol thiothixene zuclopenthixol
  • Tricyclic and piperidine: pimethixene, cyproheptadine
  • Acyclic: gilutensin

    • Alkyl(amine)s

  • Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
  • Piperidine: desoxypipradrol, budipine
  • N-alkyl-4-piperidinol: penfluridol
  • N-arylalkyl-piperidine: pimozide
  • Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
  • Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (c.f. doxanthrine and dinoxyline)
  • Pyrroloisoquinoline: JNJ-7925476
  • Indanamine: Lu 19-005
  • Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
  • Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
  • Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
  • Piperazine: amperozide
  • Triazaspiro: fluspirilene

    • Alkoxy compounds

  • Acyclic (3°C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
  • Acyclic (4°C): moxastine, Clemastine, embramine,
  • Piperazine: GBR-12935, GBR 12909, DBL-583
  • Tropine: benztropine, deptropine, etybenzatropine, difluoropine
  • Piperidine: diphenylpyraline
  • Phthalane: talopram, citalopram
  • Octahedral: nefopam
  • Benzdihydropyran: A-68930 (isochromene)

    • Amines

  • Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine dotarizine, cinnarizine.
  • Benzazepine: mianserin
  • Tetracyclic: dizocilpine

    • Other

  • Aromatic alkoxy: bifemelane, phenyltoloxamine
  • Keto: phenadoxone, methadone, dipipanone, etc.
  • Amido: dextromoramide
  • Imino: benzodiazepine, GYKI-52895
  • Sulfinyl: modafinil, adrafinil
  • Pituxate gem-diphenylcyclopropane

    • Heteroaromatic rings

  • Alkene: thiambutene, loratidine
  • Alkylamine: A-86929, amfonelic acid

    • Benzenes linked by a non-carbon atom

  • Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
  • Indolic nitrogen: sertindole
  • Oxygen: loxapine, asenapine, tyrima

    • Benzene and heterocycle linked through a non-carbon

  • Olanzapine

    • References

    Benzhydryl compounds Wikipedia
    (Text) CC BY-SA