Taking place shortly after the events of the original Ben 10, Ben, Gwen and Grandpa Max spend their evenings fighting aliens on the streets of Bellwood. During a battle against a robotic tank, Ben as Upgrade and Gwen argue about the best way to defeat it, leading to Gwen using her extraordinarily strong pink-colored magic to cast a dismantling spell on the tank while Ben is attached to it. Unknown to the children, this leads to a malfunction in the Omnitrix.
Later, after a mishap in school where the Omnitrix accidentally teleports his homework, Ben is grounded by his parents and forced to stay home and do a history report. Ben attempts to work on the report before the Omnitrix teleports his laptop away as well. Shortly afterwards, Tetrax Shard arrives and tells Ben that Azmuth has asked to meet with him. They go to meet Azmuth but are attacked by an evil version of Waybig. Tetrax and Ben fight the alien, who is also teleported into the Omnitrix, though neither of them is aware of it. Tetrax decides to take Ben to search for Azmuth and activates a new function on the Omnitrix. Before he can explain this new ability, the ship is attacked and Ben is sucked out into the atmosphere, falling to the ground as Diamondhead. It is later revealed that the new ability prevents Ben from returning to human form when he times out, simply switching alien forms. Ben as Fourarms arrives at Stonehenge and is attacked by a weaponizing Galvanic Mechamorph who demands to know about the alien that attacked Ben. Ben tries to explain he knows nothing, but the Mechamorph only continues to attack and the Mechamorph's teleporting ability causes the pair to carry their battle across the globe, destroying part of Stonehenge and nearly damaging Christ the Redeemer in Rio de Janeiro and fighting at the Great Pyramids in Egypt before arriving back in Bellwood. Ben transforms into Grey Matter and manages to escape the Mechamorph.
Meanwhile, Gwen and Grandpa Max receive a call from Ben's parents Carl and Sandra informing them that Ben has escaped the house. They go in search of him, only to find Tetrax and discover Azmuth's ship. Looking at the ship's log, they discover that Azmuth disguised it as a semi truck to track down and fix the malfunctioning Omnitrix, but crashed and was destroyed by the evil Waybig. After escaping the Mechamorph, they soon encounter Ben back at his house and Tetrax restores Ben's Omnitrix to normal just as the Mechamorph catches up to them. Gwen sees how the Omnitrix reacts after Ben returns to human form and deduces what has happened just as she, Ben, Tetrax and the Mechamorph are transported into the Omnitrix itself.
Inside, Ben and the Mechamorph continue to battle before being attacked by a swarm of Stinkflies just as Gwen and Tetrax are ambushed by a herd of Wildmutt. The four catch up with each other and they realize that the evil Waybig is inside with them just as he resurfaces. The Mechamorph, who is revealed to be Azmuth's father, attacks the Waybig in revenge for killing his son while Gwen explains to Ben about the malfunction that she caused to the Omnitrix when she cast the dismantling spell on the robotic tank while Ben was attached to it. She uses Azmuth's father to reverse the transportation and return them to Earth. Unfortunately, the Omnitrix malfunctions again and transforms Ben's parents into Wildmutt and Heatblast, causing Gwen to realize that the evil Waybig is Azmuth himself. Leaving Grandpa Max and Tetrax to handle his parents, Ben and Gwen follow Azmuth's father and Azmuth to the city park where Ben transforms into Way Big to subdue Azmuth and hold off his father while he and Gwen try to reverse the transformation. Between the two Waybigs, they do a few hundred million dollars in property damage from smashing huge building after huge building (there are most likely no one in the buildings as the battle takes place in the morning before people arrive to work in them, which may be why they are not concerned about huge loss of life). They soon convince Azmuth's father that his son is the very alien that they are fighting and the three work together to convince Azmuth to regain control of himself, use his father's Mechamorph abilities to fix the Omnitrix and return Azmuth to normal. Azmuth reprimands Ben and Gwen for their errors and reveals his father is a Galvan wielding Mechamorph-type enhanced armor. Azmuth reveals that the Omnitrix was so filled with pink mana; Gwen asks what he means, to which he simply says that she will know eventually.
Returning to Ben's house, Azmuth restores Ben's parents to normal and repairs the Rust bucket, previously destroyed in the battle, before leaving to reconcile with his own father. Ben's parents, having forgotten that they grounded Ben, tell him to enjoy his fishing trip with Grandpa Max and Gwen. Ben declines, having learned to be more responsible, and stays home to finish his history report for school. The movie ends with Ben, Gwen, and Grandpa Max on another road trip where they encounter Doctor Animo and the three prepare for another exciting battle.
Only one short is based on Ben 10: Destroy All Aliens and it's named as Ben 10: Road Trip Rumble.Tara Strong as Ben Tennyson, Upgrade, Sandra Tennyson, Computer Voice
Meagan Smith as Gwen Tennyson, Girl Student
Paul Eiding as Grandpa Max
Steven Blum as Heatblast, Mechamorph
David Fennoy as Tetrax Shard
Richard McGonagle as Four Arms, Teacher
Robert David Hall as Azmuth
Dee Bradley Baker as Stinkfly, Wildmutt, Cash Murray, Carl Tennyson, Vulpimancers, Lepidopterrans, Mutant Frog
Adam Wylie as JT
Richard Steven Horvitz as Grey Matter, Police Radio, Dispatcher
Jim Ward as Diamondhead
Fred Tatasciore as Way Big, Evil Way Big
Troy Baker as Azmuth's Father, Boy Student
Dwight Schultz as Dr. Animo
Nina Teo as Ben's Girl classmate
Xander Ching as Ben's Boy classmate
Victor Cook - Director, Supervising producer
Silas Hickey - Executive producer
Marty Isenberg - Writer
Collette Sunderman - Casting and Voice Director
Turner Broadcasting System Asia Pacific - Creative animation director
To promote the film, a toy line manufactured by Bandai has been announced to launch around the same time the film premieres. Cartoon Network Asia and Philippines held a contest for one male and one female to be "immortalized in Ben 10 history." The two winners would receive "the ultimate voice over role," assorted prizes (clothing, toys, etc.) and a VIP limo ride to walk on the "green carpet" at the Ben 10: Destroy All Aliens premiere. A similar competition was held in Malaysia and the Middle East. Filipino viewers heard the Philippine winners while the rest of Southeast Asia will hear the Malaysian kids. The winners of the contest in Philippines were later revealed to be Nina Teo and Xander Ching who are voicing two of Ben's classmates. Cartoon Network Africa held a contest to win Green Movie Tickets to the exclusive premiere of the film in Johannesburg on March 10, 2012.
The film was later released on iTunes and other electronic-based stores, such as the PlayStation Store.
Madman Entertainment released Destroy All Aliens in Region 4 on June 20, 2012. Warner Home Video released the film in Region 2 on October 1, 2012. The film was also released in Region 1 on April 16, 2013.
The film received positive reviews, as it currently holds a 83% rating on Rotten Tomatoes based on audience reviews. Emily Ashby of Commonsense Media gave Ben 10: Destroy All Aliens a 3 out of 5. Although criticizing on how much violence exists in the context of the story Ashby states that the story emphasizes the joy of family, even when that comes with rules a person does not like.
In the United States, Ben 10: Destroy All Aliens increased by double-digits across the board versus the same time period in 2011. The broadcast placed #1 in its time period in boys 2-11.
The film won the Best 3D Animated Program category at the Asian Television Awards 2012 as well as the Gold Award for Best Movie Campaign in the 2012 ProMax Awards. The award demonstrated the high level of animation talent on show in Asia and the talent available here, commented Sunny Saha from Turner International.