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Balding–Nichols model

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Balding–Nichols model

Parameters
  
0 < F < 1 {displaystyle 0
Support
  
x ∈ ( 0 ; 1 ) {displaystyle xin (0;1)!}

PDF
  
x α − 1 ( 1 − x ) β − 1 B ( α , β ) {displaystyle { rac {x^{alpha -1}(1-x)^{eta -1}}{mathrm {B} (alpha ,eta )}}!}

CDF
  
I x ( α , β ) {displaystyle I_{x}(alpha ,eta )!}

Mean
  
p {displaystyle p!}

Median
  
I 0.5 − 1 ( α , β ) {displaystyle I_{0.5}^{-1}(alpha ,eta )} no closed form

In population genetics, the Balding–Nichols model is a statistical description of the allele frequencies in the components of a sub-divided population. With background allele frequency p the allele frequencies, in sub-populations separated by Wright's FST F, are distributed according to independent draws from

B ( 1 F F p , 1 F F ( 1 p ) )

where B is the Beta distribution. This distribution has mean p and variance Fp(1 – p).

The model is due to David Balding and Richard Nichols and is widely used in the forensic analysis of DNA profiles and in population models for genetic epidemiology.


Differential equation

{ F ( x 1 ) x f ( x ) + f ( x ) ( F ( p ) + 3 F x F + p x ) = 0 }

References

Balding–Nichols model Wikipedia