Symbol IRES_Bag1 Rfam RF00222 Domain(s) Eukaryota | Alt. Symbols Bag1_IRES RNA type Cis-reg; IRES GO 0043022 | |
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The bag-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. Its effects apoptosis through IRES mediated translation of the BAG-1 protein.
When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although bag-1 translation usually occurs via a cap-dependent mechanism it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised.
References
Bag-1 internal ribosome entry site (IRES) Wikipedia(Text) CC BY-SA