Species Human Entrez 701 | Human Mouse Ensembl ENSG00000156970 | |
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Aliases BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B External IDs MGI: 1333889 HomoloGene: 933 GeneCards: BUB1B | ||
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.
Contents
Function
This gene encodes a kinase involved in spindle checkpoint function and chromosome segregation. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Increased expression of BubR1 in mice extends a healthy lifespan.
Interactions
BUB1B has been shown to interact with:
References
BUB1B Wikipedia(Text) CC BY-SA