Symbol BSD InterPro IPR005607 PDB RCSB PDB; PDBe; PDBj | Pfam PF03909 Pfam structures PDBsum structure summary | |
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In molecular biology, the BSD domain is an approximately 60-amino-acid-long protein domain named after the BTF2-like transcription factors, synapse-associated proteins and DOS2-like proteins in which it is found. It is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. The function of the BSD domain is as yet unknown.
Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small |domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues – less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain.
Some proteins known to contain one or two BSD domains are listed below: