Species Human Entrez 83990 | Human Mouse Ensembl ENSG00000136492 | |
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Aliases BRIP1, BACH1, FANCJ, OF, BRCA1 interacting protein C-terminal helicase 1 External IDs MGI: 2442836 HomoloGene: 32766 GeneCards: BRIP1 | ||
Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene.
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
This protein also appears to be important in ovarian cancer where it seems to act as a tumor suppressor.
Interactions
BRIP1 has been shown to interact with BRCA1.
References
BRIP1 Wikipedia(Text) CC BY-SA