Species Human Entrez 221927 | Human Mouse Ensembl ENSG00000106009 | |
Aliases BRAT1, BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1 External IDs MGI: 1891679 HomoloGene: 16776 GeneCards: BRAT1 | ||
BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.
Function
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.
References
BRAT1 Wikipedia(Text) CC BY-SA