Symbol BPS InterPro IPR015042 PDB RCSB PDB; PDBe; PDBj | Pfam PF08947 Pfam structures PDBsum structure summary | |
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In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/|Grb10/Grb14. It mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor. It is composed of two beta strands and a C-terminal helix.
References
BPS domain Wikipedia(Text) CC BY-SA