Entrez 57448 | Ensembl ENSG00000115760 | |
Aliases BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6 External IDs MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6 | ||
Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.
Contents
Function
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.
Interactions
BIRC6 has been shown to interact with KIF23.
Diseases
BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,).
References
BIRC6 Wikipedia(Text) CC BY-SA