Species Human Entrez 8412 | Human Mouse Ensembl ENSG00000137936 | |
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Aliases BCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3 External IDs MGI: 1352501 HomoloGene: 31181 GeneCards: BCAR3 | ||
Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.
Function
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.