Species Human Entrez 4059 | Human Mouse Ensembl ENSG00000187244 | |
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Aliases BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group) External IDs MGI: 1929940 HomoloGene: 21149 GeneCards: BCAM | ||
Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 (cluster of differentiation 239).
Contents
Function
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
BCAM has been shown to interact with Laminin, alpha 5.
References
BCAM Wikipedia(Text) CC BY-SA