Entrez 10538 | Ensembl ENSG00000156127 | |
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Aliases BATF, B-ATF, BATF1, SFA-2, SFA2, basic leucine zipper ATF-like transcription factor External IDs MGI: 1859147 HomoloGene: 4666 GeneCards: BATF | ||
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.
Contents
Function
The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.
Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.
Interactions
BATF (gene) has been shown to interact with IFI35.
References
BATF (gene) Wikipedia(Text) CC BY-SA