Species Human Entrez 573 | Human Mouse Ensembl ENSG00000107262 | |
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Aliases BAG1, BAG-1, HAP, RAP46, BCL2 associated athanogene 1 External IDs MGI: 108047 HomoloGene: 3190 GeneCards: BAG1 | ||
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.
Contents
Jim cornette plays the bag1
Function
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.
Clinical significance
BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.
Interactions
BAG1 has been shown to interact with: