Puneet Varma (Editor)

B3 domain

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Symbol
  
B3_domain

InterPro
  
IPR003340

SCOP
  
1wid

Pfam
  
PF02362

PROSITE
  
PS50863

SUPERFAMILY
  
1wid

B3 domain

The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors, from higher plants (≥40 species) (Pfam PF02362) combined with other domains (InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold (SCOP 117343); it interacts with the major groove of DNA.

Contents

B3 families

In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain:

  • ARF (Auxin Response Factors)
  • ABI3 (ABscisic acid Insensitive3)
  • RAV (Related to ABI3/VP1)
  • PDB: 1WID​ and PDB: 1YEL​ are only known NMR solution phase structures of the B3 DNA Binding Domain.

    The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold.

    References

    B3 domain Wikipedia