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Azinomycin B is a natural product that contains densely assembled functionalities with potent antitumor activity. It is isolated from Streptomyces sahachiroi which is reisolated from S. griseofuscus along with its analog azinomycin A. Azinomycin B can bind within the major groove of DNA and forms covalent interstrand crosslinks (ISCs) with the purine bases. The DNA alkylation and crosslinking by azinomycin B suggests its potent antitumor activity.
Biosynthesis
The biosynthesis of azynomycin B includes a type 1 polyketide synthase and several nonribosomal peptide synthetases.
References
Azinomycin B Wikipedia(Text) CC BY-SA