Carlile formed Attack Attack! (originally called Ambiance) around 2006 when Johnny Franck, Andrew Whiting, Nick White, and Andrew Wetzel met Carlile while playing in local high school bands. In 2008, halfway through a tour supporting Maylene and the Sons of Disaster, Carlile was replaced by Nick Barham, brother of Sleeping With Sirens drummer Gabe Barham Carlile said it was for "personal reasons" that he left the band.
On October 8, 2009, the same day Carlile announced that he was no longer a part of Attack Attack!, he officially announced the formation of his new project, Of Mice & Men, with Jaxin Hall (bassist). Their first release was "Seven Thousand Miles for What?". They also did a cover of Lady Gaga's "Poker Face", then soon after released "No Really, It's Fine". Soon after, Austin and Jaxin started to gather up the other members of the band. The band recruited several members of already-existing bands, such as Phil Manansala (lead guitarist) from A Static Lullaby, and Tino Arteaga (drummer) from Lower Definition. Their self-titled debut album was officially announced to be released on February 23, 2010, but was delayed until March 9 for finishes on production. In 2010, Austin was unable to tour with Of Mice & Men, because he needed to have major heart surgery, and his health prevented him from touring. Jerry Roush from Sky Eats Airplane served as the tour replacement for Austin. Roush then became a permanent substitute, even after Carlile was able to tour again. In September 2010, shortly after the departure of Craig Owens of Chiodos, rumours that Carlile would replace him circulated quickly, but were denied when Brandon Bolmer was announced as vocalist. A fake tweet from Carlile's account was produced making it seem that Carlile would be joining Chiodos as vocalist.
Carlile re-joined the band on January 3, 2011.
In November 2012, after the death of Suicide Silence singer Mitch Lucker, Carlile appeared on Ending is the Beginning: The Mitch Lucker Memorial Show singing the song O.C.D.
In the early morning of March 30, 2013, Carlile was arrested in Bowling Green, Ohio with drum technician Loniel Robinson II, he was later charged with felonious assault. The band missed two shows on the "Right Back at It Again" tour with A Day to Remember and Chunk! No, Captain Chunk! as a result. Carlile's mugshot was released two days later. Carlile was released on bail and ordered not to have any contact with the victim. On April 29, 2013, Carlile's original charge of felonious assault was reduced to misdemeanor assault by the judge, and he was subsequently found guilty. He was fined $1,000 plus court expenses, although $800 of the fine was suspended.
In October 2016, the band pulled out in the midst of a European tour so that Carlile could seek medical treatment after experiencing pain during a show in Portsmouth. In late November, Carlile elaborated in a series of tweets that, as a sufferer of Marfan syndrome, he wouldn't "get better" and that he had undergone multiple surgeries "just so I can function/live."
On December 30, 2016, Austin Carlile posted on his Instagram and Twitter an open letter stating that he's leaving the band to focus on healing, moving on, and getting better after settling in Costa Rica, saying "...with the closing of one door, another will open." He also said that he "will not stop playing music" and that he is "still able to sing and I'm hungry for what is next to come even though I have no idea what that may be.".
It was revealed on February 17, 2017 that one of the other reasons Carlile had left the band was because he wasn't allowed to write what he wanted on the next record. In a reply to an Instagram comment about whether or not he would be working with Of Mice & Men in the future, he said "No I will no longer be writing with them, one of the reasons I left. They weren't going to let me write what I wanted on next record. That's not gonna happen. I will write what I want despite what that means giving up."
Carlile lost his mother when he was 17.. As of 2016, carlile identifies himself as a Christian and was baptized. []