Atrolysin E

Atrolysin E (EC 3.4.24.44, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of Asn³-Gln, Ser⁹-His and Ala¹⁴-Leu bonds in insulin B chain and Tyr¹⁴-Gln and Thr⁸-Ser in A chain. Cleaves type IV collagen at Ala⁷³-Gln in alpha1(IV) and at Gly⁷-Leu in alpha2(IV)

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).