ATC code none PubChem CID 129869 UNII MG7D3QD743 Molar mass 336.598 g/mol | CAS Number 123018-47-3 ChemSpider 114962 KEGG D03003 | |
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Atiprimod (INN, codenamed SK&F106615) is a substance being studied in the treatment of certain multiple myelomas and other advanced cancers. It may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. This drug is also being researched as a potential treatment for various autoimmune diseases. It was first developed by GlaxoSmithKline as a potential treatment for rheumatoid arthritis. The substance is also known as azaspirane, although this more properly refers to the class of chemicals to which atiprimod belongs.
Contents
This compound has also been shown to kill mantle cell lymphoma cells in vitro.
Mechanism of action
Atiprimod has been shown to inhibit angiogenesis (growth of blood vessels) in a blood vessel model using chicken eggs. It is thought to inhibit the secretion of vascular endothelial growth factor (VEGF), a growth factor that promotes angiogenesis.
Chemistry
Atiprimod is a amphiphilic compound and a cation at neutral pH.